Multifactorial analysis of changes in body mass index across the adult life course: a study with 65 years of follow-up
Open Access
- 6 November 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in International Journal of Obesity
- Vol. 38 (8), 1133-1141
- https://doi.org/10.1038/ijo.2013.204
Abstract
Background: Although the negative consequences on health of being obese are well known, most adults gain weight across the lifespan. The general increase in body mass index (BMI) is mainly considered to originate from behavioral and environmental changes; however, few studies have evaluated the influence of these factors on change in BMI in the presence of genetic risk. We aimed to study the influence of multifactorial causes of change in BMI, over 65 years. Methods and Findings: Totally, 6130 participants from TwinGene, who had up to five assessments, and 536 from the Swedish Adoption/Twin Study of Aging, who had up to 12 assessments, ranging over 65 years were included. The influence of lifestyle factors, birth cohort, cardiometabolic diseases and an individual obesity genetic risk score (OGRS) based on 32 single nucleotide polymorphisms on change in BMI was evaluated with a growth model. For both sexes, BMI increased from early adulthood to age of 65 years, after which the increase leveled off; BMI declined after age of 80 years. A higher OGRS, birth after 1925 and cardiometabolic diseases were associated with higher average BMI and a steeper increase in BMI prior to 65 years of age. Among men, few factors were identified that influence BMI trajectories in late life, whereas for women type 2 diabetes mellitus and dementia were associated with a steeper decrease in BMI after the age of 65 years. Conclusions: There are two turning points in BMI in late adulthood, one at the age of 65 years and one at the age 80 years. Factors associated with an increase in BMI in midlife were not associated with an increase in BMI after the age of 65 years. These findings indicate that the causes and consequences of change in BMI differ across the lifespan. Current health recommendations need to be adjusted accordingly.Keywords
This publication has 34 references indexed in Scilit:
- The Swedish Twin Registry: Establishment of a Biobank and Other Recent DevelopmentsTwin Research and Human Genetics, 2012
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexNature Genetics, 2010
- Being Overweight in Midlife Is Associated With Lower Cognitive Ability and Steeper Cognitive Decline in Late LifeThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2009
- Genetics of Tracking of Body Mass Index from Birth to Late Middle Age: Evidence from Twin and Family StudiesObesity Facts, 2009
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- Incident dementia in women is preceded by weight loss by at least a decadeNeurology, 2007
- Prediction of Coronary Heart Disease Risk using a Genetic Risk Score: The Atherosclerosis Risk in Communities StudyAmerican Journal of Epidemiology, 2007
- Processing Speed and Longitudinal Trajectories of Change for Cognitive Abilities: The Swedish Adoption/Twin Study of AgingAging, Neuropsychology, and Cognition, 2004
- Body Mass Index, Weight Change, and Death in Older Adults: The Systolic Hypertension in the Elderly ProgramAmerican Journal of Epidemiology, 2002
- Obesity as a medical problemNature, 2000