Supplementation of fenugreek leaves to diabetic rats. Effect on carbohydrate metabolic enzymes in diabetic liver and kidney
- 5 December 2003
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 17 (10), 1231-1233
- https://doi.org/10.1002/ptr.1357
Abstract
The present study was designed to evaluate the effect of supplementation of fenugreek leaves, an indigenous plant widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus, in streptozotocin induced diabetic rats. Supplementation of the diet with fenugreek leaves showed a significant effect on hyperglycaemia, hypoinsulinaemia and glycosylated haemoglobin in streptozotocin diabetic rats. Fenugreek leaves improved the body weight and liver glycogen. Fenugreek leaves also showed a significant effect on key carbohydrate metabolic enzymes in diabetic rats. The effect of fenugreek leaves was found to be similar to that of glibenclamide. Thus, fenugreek leaves exhibited antidiabetic action in streptozotocin-induced diabetic rats. Insulin restored all the parameters to near normal levels in diabetic rats. Copyright © 2003 John Wiley & Sons, Ltd.Keywords
This publication has 5 references indexed in Scilit:
- Effect of Coccinia indica on Blood Glucose, Insulin and Key Hepatic Enzymes in Experimental DiabetesPharmaceutical Biology, 2002
- Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteersEastern Mediterranean Health Journal, 2000
- Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic ratsJournal of Ethnopharmacology, 1997
- Effect ofSyzigium cumini extracts on hepatic hexokinase and glucose-6-phosphatase in experimental diabetesPhytotherapy Research, 1997
- Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjectsNutrition Research, 1986