Screening for Lipid Disorders in Children: US Preventive Services Task Force Recommendation Statement
- 1 July 2007
- journal article
- practice guideline
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 120 (1), e215-e219
- https://doi.org/10.1542/peds.2006-1812
Abstract
The US Preventive Services Task Force (USPSTF) concludes that the evidence is insufficient to recommend for or against routine screening for lipid disorders in infants, children, adolescents, or young adults (up to age 20) (I recommendation). ### Importance There is good evidence that children with lipid disorders (dyslipidemia) are at risk for becoming adults with lipid disorders. ### Detection For children with familial dyslipidemia, the group most likely to benefit from screening, use of family history in screening may be inaccurate because of variability of definitions and unreliability of information. Serum lipid levels are accurate screening tests for childhood dyslipidemia, although many children with multifactorial types of dyslipidemia would have normal lipid levels in adulthood. Fifty percent of children and adolescents with dyslipidemia will have dyslipidemia as adults. ### Benefits of Detection and Early Treatment* Trials of statin drugs in children with monogenic dyslipidemia (defined below in “Clinical Considerations”) indicate improved total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) measures. For children with multifactorial types of dyslipidemia, there is no evidence that diet or exercise interventions in childhood lead to improved lipid profiles or better health outcomes in adulthood. ### Harms of Detection and Early Treatment Potential harms of screening may include labeling of children whose dyslipidemia would not persist into adulthood or cause health problems, although evidence is lacking. Adverse effects from lipid-lowering medications and low-fat diets, including potential long-term harms, have been inadequately evaluated in children. ### USPSTF Assessment The USPSTF was unable to determine the balance between potential benefits and harms for routinely screening children and adolescents for dyslipidemia. Address correspondence to Ned Calonge, MD, MPH, Colorado Department of Public Health and Environment, 4300 Cherry Creek Dr S, Denver, CO 80246. E-mail: ned.calonge{at}state.co.usKeywords
This publication has 15 references indexed in Scilit:
- Screening and Treatment for Lipid Disorders in Children and Adolescents: Systematic Evidence Review for the US Preventive Services Task ForcePediatrics, 2007
- Drug Therapy of High-Risk Lipid Abnormalities in Children and AdolescentsCirculation, 2007
- Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemiaJournal of Inherited Metabolic Disease, 2003
- American Heart Association Guidelines for Primary Prevention of Atherosclerotic Cardiovascular Disease Beginning in ChildhoodCirculation, 2003
- Long-Term Safety and Efficacy of a Cholesterol-Lowering Diet in Children With Elevated Low-Density Lipoprotein Cholesterol: Seven-Year Results of the Dietary Intervention Study in Children (DISC)Published by American Academy of Pediatrics (AAP) ,2001
- Acceptability and compliance with two forms of cholestyramine in the treatment of hypercholesterolemia in children: A randomized, crossover trialThe Journal of Pediatrics, 1997
- Efficacy and safety of cholestyramine therapy in peripubertal and prepubertal children with familial hypercholesterolemiaThe Journal of Pediatrics, 1996
- Efficacy and Safety of Lowering Dietary Intake of Fat and Cholesterol in Children With Elevated Low-Density Lipoprotein CholesterolJama-Journal Of The American Medical Association, 1995
- Efficacy and safety of lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol. The Dietary Intervention Study in Children (DISC). The Writing Group for the DISC Collaborative Research GroupJama-Journal Of The American Medical Association, 1995
- Tracking of serum lipids and lipoproteins in children over an 8-year period: The Bogalusa heart studyPreventive Medicine, 1985