Cellular Factors Required for Lassa Virus Budding
- 15 April 2006
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 80 (8), 4191-4195
- https://doi.org/10.1128/jvi.80.8.4191-4195.2006
Abstract
It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.Keywords
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