Cardiovascular changes after pulmonary embolism from injecting calcium phosphate cement
- 6 February 2007
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 82B (2), 526-532
- https://doi.org/10.1002/jbm.b.30758
Abstract
Concerns have been raised that the use of calcium phosphate (CaP) cements for the augmentation of fractured, osteoporotic bones may aggravate cardiovascular deterioration in the event of pulmonary cement embolism by stimulating coagulation. The aim of the present study was therefore to investigate the cardiovascular changes after pulmonary embolism of CaP cement using an animal model. In 14 sheep, 2.0 mL CaP or polymethylmethacrylate cement were injected intravenously. Cardiovascular parameters and antithrombin levels were monitored until 60 min postinjection. Postmortem, lungs were subjected to CT scanning, and 3D reconstruction of the cement was performed. Intravenous injection of CaP cement resulted in a more severe increase in pulmonary arterial pressure and decrease in arterial blood pressure. Disintegration of the CaP cement seemed to be the reason for the more severe reaction. There was no evidence of thromboembolism. Disintegration of CaP cement in circulating blood does not only compromise the mechanical properties, but also represents a risk of cardiovascular complications. Reliable cohesion of CaP cements in an aqueous environment is essential for clinical applications such as osteoporotic bone augmentation. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007Keywords
This publication has 28 references indexed in Scilit:
- Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical StudiesSpine, 2006
- Technological issues for the development of more efficient calcium phosphate bone cements: A critical assessmentBiomaterials, 2005
- Calcium phosphate cement leakage after percutaneous vertebroplasty for osteoporotic vertebral fractures: risk factor analysis for cement leakageJournal of Neurosurgery: Spine, 2005
- Selective protein adsorption and blood compatibility of hydroxy‐carbonate apatitesJournal of Biomedical Materials Research Part A, 2004
- Severe Hypercapnia Due to Pulmonary Embolism of Polymethylmethacrylate During VertebroplastyAnesthesia & Analgesia, 2004
- The Effect of Cement Augmentation on the Load Transfer in an Osteoporotic Functional Spinal UnitSpine, 2003
- Changing patterns of insulin-like growth factor—I and glucose-suppressed growth hormone levels after pituitary surgery in patients with acromegalyJournal of Neurosurgery, 2002
- Fat Embolism and Acute Hypotension During VertebroplastySpine, 2002
- Toxic effects of methylmethacrylate monomer on leukocytes and endothelial cells in vitroActa Orthopaedica, 1994
- Cardiovascular Effects of Implanted Acrylic Bone CementBMJ, 1971