Different surgical strategies of patients with intravenous leiomyomatosis
Open Access
- 1 September 2016
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Medicine
- Vol. 95 (37), e4902
- https://doi.org/10.1097/md.0000000000004902
Abstract
Intravenous leiomyomatosis (IVL) is a rare benign tumor. The study aimed to assess outcomes of patients treated surgically for IVL. Between November 2002 and January 2015, 76 patients were treated for IVL. The stage of IVL was evaluated preoperatively by echocardiography and enhanced computerized tomography (CT) scan, and graded into 4 stages according to intravascular tumor progression. We recorded age, lower limb edema before surgery, surgical parameters, and hospitalization expenses. Patients were followed up every 6 months and tumor recurrence was assessed by CT and ultrasound. Patients were followed up for a mean of 4.5 ± 2.5 years (range 1–13 years) and there was no operative, hospital, or long-term mortality or were lost to follow-up. The rate of lower extremity edema, amount of blood loss, postoperative transfusion, length of intensive care unit (ICU) stay, postoperative hospitalization, and hospitalization expenses differed significantly between patients at different presurgery stages. Tumors recurred in 4 of 7 patients with stage I IVL that opted for surgery that preserved the ovaries and uterus. No recurrence was observed in patients graded stage II or more, in all of which the uterus and ovaries were removed. Recurrence was observed in only 4 of 76 cases of IVL, all of whom opted for surgery that spared the ovaries and uterus. Different surgical strategies should be decided based on the staging to completely remove the tumor and ensure the safety of patients. Removal of both ovaries is necessary for inhibiting tumor growth and avoiding recurrence.Keywords
This publication has 27 references indexed in Scilit:
- One-Stage Complete Removal of Intracardiac Leiomyomatosis without Cardiac ArrestThe Thoracic and Cardiovascular Surgeon, 2012
- Pulmonary Artery Embolization of Intravenous Leiomyomatosis Extending into the Right AtriumThe Korean Journal of Thoracic and Cardiovascular Surgery, 2011
- Intravenous leiomyomatosis with inferior vena cava and heart extensionJournal of Vascular Surgery, 2009
- Diagnostic and Surgical Issues in Emergency Presentation of a Pelvic Leiomyoma in the Right HeartThe Annals of Thoracic Surgery, 2009
- Intravenous leiomyomatosis treated with aromatase inhibitor therapyInternational Journal of Gynecology & Obstetrics, 2008
- TEE-Guided One-Stage Excision of Intravenous Leiomyomatosis With Cardiac Extension Through an Abdominal ApproachJournal of Cardiothoracic and Vascular Anesthesia, 2006
- Intravenous Leiomyomatosis: Molecular and Cytogenetic Analysis of a CaseLaboratory Investigation, 2002
- Pulmonary embolectomy for intravenous uterine leiomyomatosisAmerican Heart Journal, 1994
- Intravenous leiomyomatosis: a case report emphasizing the vascular componentHistopathology, 1988
- Intravenous Leiomyomatosis of the Uterus and PelvisAnnals of Surgery, 1959