Exploring the cellular accumulation of metal complexes
- 23 December 2009
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- Vol. 39 (5), 1159-1170
- https://doi.org/10.1039/b922209j
Abstract
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters. Emphasis is placed on the methods used to examine cellular accumulation, to identify the mechanism(s) of uptake, and to monitor possible efflux. Conjugation strategies that have been employed to improve the cellular uptake characteristics of metal complexes are also described.This publication has 128 references indexed in Scilit:
- Fluorescein Redirects a Ruthenium−Octaarginine Conjugate to the NucleusJournal of the American Chemical Society, 2009
- DNA Mismatch Binding and Antiproliferative Activity of Rhodium MetalloinsertorsJournal of the American Chemical Society, 2009
- Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cellsJournal of Analytical Atomic Spectrometry, 2008
- Mechanism of Cellular Uptake of a Ruthenium Polypyridyl ComplexBiochemistry, 2008
- New trends for metal complexes with anticancer activityCurrent Opinion in Chemical Biology, 2008
- Metallo-intercalators and metallo-insertorsChemical Communications, 2007
- Conjugated Platinum(IV)−Peptide Complexes for Targeting Angiogenic Tumor VasculatureBioconjugate Chemistry, 2007
- Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug DesignJournal of the American Chemical Society, 2007
- Methods to Explore Cellular Uptake of Ruthenium ComplexesJournal of the American Chemical Society, 2006
- Cellular processing of platinum anticancer drugsNature Reviews Drug Discovery, 2005