Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient
- 23 December 2008
- journal article
- case report
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 52 (3), 494-503
- https://doi.org/10.1007/s00125-008-1237-z
Abstract
Simultaneous kidney–pancreas transplantation is an established treatment for patients with type 1 diabetes and end-stage renal failure, even though restored beta cell function may become affected by recurrent islet autoimmunity or graft rejection. We characterised infiltrating lymphocytes isolated from a pancreatic graft with normal endocrine function in a kidney–pancreas recipient with type 1 diabetes.This publication has 28 references indexed in Scilit:
- Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell TransplantationPLOS ONE, 2008
- Reduced immunosuppression in pediatric liver-intestine transplant recipients with CD8+CD28− T-suppressor cellsHuman Immunology, 2005
- Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitusJournal of Autoimmunity, 2004
- Alloantigen specific CD8+CD28− FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivityInternational Immunology, 2004
- Central Memory and Effector Memory T Cell Subsets: Function, Generation, and MaintenanceAnnual Review of Immunology, 2004
- High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cellsTransplant Immunology, 2003
- Regulatory CD8+CD28− T cells in heart transplant recipientsHuman Immunology, 2003
- Distinct TCRAV and TCRBV repertoire and CDR3 sequence of T lymphocytes clonally expanded in blood and GVHD lesions after human allogeneic bone marrow transplantationBone Marrow Transplantation, 2002
- Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4JCI Insight, 1999
- T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteinsNature, 1990