Ethnic differences in post-menopausal plasma oestrogen levels: high oestrone levels in Japanese-American women despite low weight
Open Access
- 5 May 2000
- journal article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 82 (11), 1867-1870
- https://doi.org/10.1054/bjoc.1999.1082
Abstract
Breast cancer incidence in Japanese-American women is approaching that of US Whites. We investigated whether this shift is paralleled by similar post-menopausal plasma hormone levels in the two ethnic groups. We also included African-American and Latina women to further our understanding of possible ethnic differences in oestrogen metabolism. We measured androstenedione (A), oestrone (E1) and oestradiol (E2) in 30 Japanese-American, 39 non-Latina White (‘White’), 66 African-American and 58 Latina women. The (age-adjusted) geometric mean E1 levels were 34 pg ml–1 in Japanese-Americans, 28 pg ml–1 in Whites, 35 pg ml–1 in African-Americans and 31 pg ml–1in Latinas. After adjustment for body mass index, Japanese-Americans had the highest mean E1 value of all groups and this was statistically significantly greater than the value for Whites (Pt-test= 0.05). The geometric mean A concentrations were also highest in Japanese-Americans. There was little ethnic difference in E2 levels. In conclusion, post-menopausal plasma oestrogen levels in Japanese-American women are at least as high as those in Whites. © 2000 Cancer Research CampaignKeywords
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