A comprehensive guide to the ROMK potassium channel: form and function in health and disease
- 1 October 2009
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Renal Physiology
- Vol. 297 (4), F849-F863
- https://doi.org/10.1152/ajprenal.00181.2009
Abstract
The discovery of the renal outer medullary K+channel (ROMK, Kir1.1), the founding member of the inward-rectifying K+channel (Kir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.Keywords
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