A novel 4.1 ezrin radixin moesin (FERM)‐containing protein, ‘Willin’
- 25 August 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (22), 5089-5094
- https://doi.org/10.1016/j.febslet.2005.07.097
Abstract
The 4.1 superfamily of proteins contain a 4 .1 E zrin R adixin M oesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.Keywords
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