Mutagenic and Transforming Effects of Soft-X-rays with Resonance Energy of Phosphorus K-absorption Edge
- 1 January 1992
- journal article
- Published by Taylor & Francis Ltd in International Journal of Radiation Biology
- Vol. 61 (2), 161-168
- https://doi.org/10.1080/09553009214550771
Abstract
Syrian golden hamster embryo (SHE) cells were exposed to synchrotron-produced monochromatic X-rays at 5.747 (2.159 keV), 5.763 (2.153 keV) and 5.779 A (2.147 keV). Although X-rays of all wavelengths induced mutations and chromatid aberrations in a dose-dependent manner, when cells were irradiated with 2.153 keV X-rays, which correspond to the resonance energy of the phosphorus K-absorption edge, the frequencies of mutation and chromatid aberration at equal dose levels were higher than for X-rays of the other wavelengths. At equal survival levels, however, there was no difference in the frequencies of mutations and chromatid aberrations in cells irradiated with soft X-rays. On the other hand, the frequency of morphological transformation in cells irradiated with 2.147 keV X-rays was higher than those irradiated with 2.153 keV and 2.159 keV X-rays. The relative biological effectiveness compared to cobalt-60 gamma-rays in morphological transformation was 2.8 for 2.147 keV, 1.1 for 2.159 keV and 1.0 for 2.153 keV at a 37% survival level.Keywords
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