Development and Characterization of Microfabricated Disposable Gold Working Electrodes for High-Performance Ion Chromatography and Integrated Pulsed Amperometric Detection
- 21 December 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 75 (3), 572-579
- https://doi.org/10.1021/ac0204754
Abstract
We have developed a new type of microfabricated thin-film electrode on polymeric substrates. The microfabrication process allows for inexpensive and reproducible mass production of disposable working electrodes for high-performance ion chromatography and integrated pulsed amperometric detection (IPAD). These microfabricated electrodes are disposable and have been optimized for use in flow-through low-dead-volume electrochemical cells. The analytical performance of microfabricated gold electrodes was characterized with the help of the IPAD method for amino acid detection under alkaline conditions required for anion-exchange separations. When used with a new optimized six-potential IPAD waveform, the electrodes functioned properly for weeks. Compared to nondisposable working electrodes, the disposable working electrodes generated equal or better results in the limit of detection, linearity of calibration, and reproducibility. Disposable electrodes make it possible to avoid polishing and reconditioning, which are required with nondisposable electrodes.Keywords
This publication has 16 references indexed in Scilit:
- Meetings: ACS in New Orleans.Analytical Chemistry, 1999
- Anodic Stripping Voltammetry Coupled On-Line with Inductively Coupled Plasma Mass Spectrometry: Optimization of a Thin-Layer Flow Cell System for Analyte Signal EnhancementAnalytical Chemistry, 1997
- Selective Electrochemical Detection Using a Split Disk Array Electrode in a Thin-Layer Radial Flow SystemAnalytical Chemistry, 1996
- Carbon film based ring‐disk and split‐disk dual electrodes as detectors for microbore liquid chromatographyElectroanalysis, 1996
- Self-Assembled .omega.-Hydroxyalkanethiol Monolayers with Internal Functionalities: Electrochemical and Infrared Structural Characterizations of Ether-Containing MonolayersThe Journal of Physical Chemistry, 1995
- Self-Assembled Monolayers containing PolydiacetylenesJournal of the American Chemical Society, 1994
- Comparison of pulsed coulometric detection and potential-sweep-pulsed coulometric detection for underivatized amino acids in liquid chromatographyAnalytical Chemistry, 1989
- Theoretical and practical limitations on the optimization of amperometric detectorsAnalytical Chemistry, 1984
- Theoretical comparison of the performance of electrochemical flow-through detectorsAnalytica Chimica Acta, 1982
- The behaviour of an electrochemical detector used in liquid chromatography and continuous flow voltammetry: Part 1. Mass transport-limited currentAnalytica Chimica Acta, 1978