Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer
Open Access
- 12 March 2013
- journal article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 15 (2), R22
- https://doi.org/10.1186/bcr3398
Abstract
High prion protein (PrP) levels are associated with breast, colon and gastric cancer resistance to treatment and with a poor prognosis for the patients. However, little is known about the underlying molecular mechanism(s) regulating human PrP gene (PRNP) expression in cancers. Because endoplasmic reticulum (ER) stress is associated with solid tumors, we investigated a possible regulation of PRNP gene expression by ER stress.Keywords
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