The association of the dopamine transporter gene and the dopamine receptor 2 gene with delirium, a meta‐analysis
- 18 February 2010
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 153B (2), 648-655
- https://doi.org/10.1002/ajmg.b.31034
Abstract
Delirium is the most common neuropsychiatric syndrome in elderly ill patients. Previously, associations between delirium and the dopamine transporter gene (solute carrier family 6, member 3 (SLC6A3)) and dopamine receptor 2 gene (DRD2) were found. The aim of this study was to validate whether markers of the SLC6A3 and DRD2 genes are were associated with delirium in independent populations. Six European populations collected DNA of older delirious patients. Associations were determined per population and results were combined in a meta‐analysis. In total 820 medical inpatients, 185 cardiac surgery patients, 134 non‐cardiac surgery patients and 502 population‐based elderly subjects were included. Mean age was 82 years (SD 7.5 years), 598 (36%) were male, 665 (41%) had pre‐existing cognitive impairment, and 558 (34%) experienced delirium. The SLC6A3 rs393795 homozygous AA genotype was more frequent in patients without delirium in all populations. The meta‐analysis showed an Odds Ratio (OR) for delirium of 0.4 (95% confidence interval (C.I.) 0.2–0.6, P = 0.0003) for subjects with AA genotype compared to the AG and GG genotypes. SLC6A3 marker rs1042098 showed no association with delirium. In meta‐analysis the DRD2 rs6276 homozygous GG genotype showed an OR of 0.8 for delirium (95% C.I. 0.6–1.1, P = 0.24). When subjects were stratified for cognitive status the rs6276 GG genotype showed ORs of 0.6 (95% C.I. 0.4–1.0, P = 0.06) and 0.8 (95% C.I. 0.5–1.5, P = 0.51) for delirium in patients with and without cognitive impairment, respectively. In independent cohorts, a variation in the SLC6A3 gene and possibly the DRD2 gene were found to protect for delirium.Keywords
This publication has 32 references indexed in Scilit:
- Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with deliriumAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 2009
- The genetics of deliriaInternational Review of Psychiatry, 2009
- Screening methods for delirium: early diagnosis by means of objective quantification of motor activity patterns using wrist-actigraphyInteractive CardioVascular and Thoracic Surgery, 2008
- Neurofibrillary tau pathology modulated by genetic variation of α‐synucleinAnnals of Neurology, 2008
- Standardizing Assessment of Elderly People in Acute Care: The interRAI Acute Care InstrumentJournal of the American Geriatrics Society, 2008
- Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients*Critical Care Medicine, 2007
- A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validationPsychological Medicine, 1994
- A New Clinical Scale for the Staging of DementiaThe British Journal of Psychiatry, 1982
- Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily LivingThe Gerontologist, 1969
- Studies of Illness in the AgedJAMA, 1963