Subtle motor disturbances in PREDICT-PD participants

Abstract

Objective The PREDICT-PD study aims to identify increased risk of Parkinson’'s disease (PD) using online assessments of previously identified risk and early features of PD and an evidence-based scoring algorithm. We sought to determine whether higher risk participants (defined as those above the 15th centile of risk estimates) were more likely to have mild parkinsonian signs compared with lower risk participants. Methods Video recordings of neurological examinations, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III, of 208 individuals who had previously completed an online risk assessment were scored blindly and independently by two movement-disorders experts. Higher risk and lower risk subjects were compared for MDS-UPDRS part III score (and derivations of this) to identify subclinical parkinsonism, and association of risk estimates with MDS-UPDRS III scores assessed. Results Higher risk subjects had significantly higher median UPDRS part III scores (3, IQR 1–5.5) than lower risk subjects (1, IQR 0–3.0; pConclusions The PREDICT-PD algorithm identifies a population with an increased rate of motor disturbances.