Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains
- 30 September 2008
- journal article
- research article
- Published by Wiley in Genes, Brain and Behavior
- Vol. 7 (7), 761-769
- https://doi.org/10.1111/j.1601-183x.2008.00415.x
Abstract
We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open-field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open-field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open-field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors.Keywords
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