Role of PPAR in Hepatic Carbohydrate Metabolism
Open Access
- 30 September 2010
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2010, 1-12
- https://doi.org/10.1155/2010/572405
Abstract
Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR in balancing glucose homeostasis as well. By using PPAR ligands and PPAR mice, several crucial genes were shown to be regulated by PPAR in a direct or indirect way. We here review recent evidence that PPAR contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.Keywords
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