Effect of Korean Red Ginseng on Arterial Stiffness in Subjects with Hypertension
- 1 January 2011
- journal article
- research article
- Published by Mary Ann Liebert Inc in The Journal of Alternative and Complementary Medicine
- Vol. 17 (1), 45-49
- https://doi.org/10.1089/acm.2010.0065
Abstract
Objectives: Korean red ginseng (KRG) improves endothelial function and lower blood pressure (BP), which may affect arterial stiffness. The present study evaluated whether KRG treatment could improve arterial stiffness in subjects with hypertension. Subjects and methods: Eighty (80) participants with hypertension who were treated with antihypertensive agents were randomly assigned to an active (KRG 3 g/day) or a placebo treatment group in a double-blind manner. Participants were not allowed to change their antihypertensive medications. Systolic BP (SBP) and diastolic BP (DBP) were measured at baseline, and at 1, 2, and 3 months. Arterial stiffness was assessed by the measurement of brachial–ankle pulse wave velocity (baPWV) at baseline, and at 1 and 3 months. Results: Thirty (30) subjects in the active group (AG) and 34 subjects in the placebo group (PG) completed 3 months of treatment and then a per-protocol analysis was done. SBP and DBP at baseline, and at 1, 2, and 3 months were not different between the AG and PG (p > 0.05). After 3 months of treatment, SBP of AG was not changed from SBP at baseline. However, DBP of AG, and SBP and DBP of PG after 3 months of treatment were significantly reduced (p < 0.05). baPWV of both groups was significantly reduced at 1 and 3 months (p < 0.05), but was not different between the groups at each time point. Analysis after adjustment for age, time-dependent mean arterial BP, heart rate, and levels of fasting blood glucose and triglycerides showed no significant difference between AG and PG in changes of baPWV from baseline to 1 and 3 months (p > 0.05). Conclusions: Three (3) months' treatment with KRG did not improve arterial stiffness in subjects with hypertension.Keywords
This publication has 23 references indexed in Scilit:
- Measurements of Arterial Stiffness: Methodological AspectsKorean Circulation Journal, 2008
- Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic EventsArteriosclerosis, Thrombosis, and Vascular Biology, 2003
- Validation of the Omron HEM-907 device for blood pressure measurementBlood Pressure Monitoring, 2002
- Validity, Reproducibility, and Clinical Significance of Noninvasive Brachial-Ankle Pulse Wave Velocity Measurement.Hypertension Research, 2002
- Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive PatientsHypertension, 2001
- Impact of Aortic Stiffness Attenuation on Survival of Patients in End-Stage Renal FailureCirculation, 2001
- Effects of Red Ginseng upon Vascular Endothelial Function in Patients with Essential HypertensionThe American Journal of Chinese Medicine, 2000
- Impact of Aortic Stiffness on Survival in End-Stage Renal DiseaseCirculation, 1999
- Effect of Red Ginseng on Blood Pressure in Patients with Essential Hypertension and White Coat HypertensionThe American Journal of Chinese Medicine, 1998
- Panax ginseng pharmacology: A nitric oxide link?Biochemical Pharmacology, 1997