Cold atmospheric plasma, a novel promising anti-cancer treatment modality
Top Cited Papers
Open Access
- 27 February 2017
- journal article
- review article
- Published by Impact Journals, LLC in Oncotarget
- Vol. 8 (9), 15977-15995
- https://doi.org/10.18632/oncotarget.13304
Abstract
Over the past decade, cold atmospheric plasma (CAP), a near room temperature ionized gas has shown its promising application in cancer therapy. Two CAP devices, namely dielectric barrier discharge and plasma jet, show significantly anti-cancer capacity over dozens of cancer cell lines in vitro and several subcutaneous xenograft tumors in vivo. In contrast to conventional anti-cancer approaches and drugs, CAP is a selective anti-cancer treatment modality. Thus far establishing the chemical and molecular mechanism of the anti-cancer capacity of CAP is far from complete. In this review, we provide a comprehensive introduction of the basics of CAP, state of the art research in this field, the primary challenges, and future directions to cancer biologists.Keywords
This publication has 160 references indexed in Scilit:
- Preferential killing of human lung cancer cell lines with mitochondrial dysfunction by nonthermal dielectric barrier discharge plasmaCell Death & Disease, 2013
- Restoration of Sensitivity in Chemo — Resistant Glioma Cells by Cold Atmospheric PlasmaPLOS ONE, 2013
- A Preliminary Study of the Effect of DBD Plasma and Osmolytes on T98G Brain Cancer and HEK Non-Malignant CellsMolecules, 2013
- Targeting the cancer cell cycle by cold atmospheric plasmaScientific Reports, 2012
- Cold plasma selectivity and the possibility of a paradigm shift in cancer therapyBritish Journal of Cancer, 2011
- The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3Structure, 2011
- Regulation of cancer cell metabolismNature Reviews Cancer, 2011
- Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signalingProceedings of the National Academy of Sciences of the United States of America, 2010
- Altered redox status accompanies progression to metastatic human bladder cancerFree Radical Biology & Medicine, 2008
- Aquaporins with selectivity for unconventional permeantsCellular and Molecular Life Sciences, 2007