Cytokine receptor signalling
- 1 October 1995
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 377 (6550), 591-594
- https://doi.org/10.1038/377591a0
Abstract
Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex. Among these are the signal transducers and activators of transcription (STATs), a family of transcription factors that contribute to the diversity of cytokine responses.Keywords
This publication has 89 references indexed in Scilit:
- Interleukin‐6‐induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin‐6 target gene inductionFEBS Letters, 1995
- Phosphatidylinositol-3-OH kinase direct target of RasNature, 1994
- The IRS-1 signaling systemTrends in Biochemical Sciences, 1994
- The Angiotensin II AT1 Receptor Is Tyrosine and Serine Phosphorylated and can Serve as a Substrate for the SRC Family of Tyrosine KinasesBiochemical and Biophysical Research Communications, 1994
- Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6Science, 1994
- Cytokine signal transductionCell, 1994
- Lymphocyte responses and cytokinesCell, 1994
- Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoterCell, 1993
- How receptor tyrosine kinases activate rasTrends in Biochemical Sciences, 1993
- INTERFERONS AND THEIR ACTIONSAnnual Review of Biochemistry, 1987