Germinoma involving the basal ganglia in children
- 29 September 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in Child's Nervous System
- Vol. 24 (1), 71-78
- https://doi.org/10.1007/s00381-007-0495-2
Abstract
Background Germinoma originating in the basal ganglia is rare, and the majority of reported papers have been from Japan. In a collection of the first 500 cases of primary brain tumors in children in Taipei Veterans General Hospital, six pure germinomas with tissue diagnosis situated in this location. Materials and methods We reviewed the clinical features, neuroimaging studies, tumor markers, management, and outcome of these six patients. Results All of them were boys. The median age of onset of symptoms was 9.7 years. They uniformly presented with hemiparesis. The average duration of symptoms before surgical management was 1 year. One patient had bilateral basal ganglia tumors. Serum β-human chorionic gonadotropin levels was elevated (128 mIU/ml) in one patient. Longitudinal neuroimaging studies in four patients clearly showed that the tumor arose as a tiny lesion at the lenticular nucleus. Five patients had cysts within tumors. Five patients received partial, subtotal, to total resection. One patient had stereotactic biopsy of the tumors. Postoperative primary adjuvant therapies included radiotherapy, chemotherapy alone, and combined chemotherapy and radiotherapy. Five patients survived, and one patient died of radiation-induced sarcoma with median follow-up period of 13.7 years. Local recurrence was observed in all of three patients after solitary postoperative chemotherapy. Conclusions The lenticular nucleus is a significant locus for germinomas and can be bilateral. Although rarely reported in Western countries, it does exist in Taiwan as well. Treatment of germinomas in this specific location is similar to germinoma in other intracranial locations.Keywords
This publication has 28 references indexed in Scilit:
- Primary pediatric brain tumorsCancer, 2005
- Lack of benefit of spinal irradiation in the primary treatment of intracranial germinomaCancer, 2005
- Germinoma causing wallerian degenerationJournal of Neurosurgery, 1998
- A 14-Year-Old Male With Basal Ganglia TumorPediatric Neurosurgery, 1997
- Germinomas of the basal ganglia and thalamus: MR findings and a comparison between MR and CT.American Journal of Roentgenology, 1994
- Sequential MRI findings in a patient with a germ cell tumor in the basal gangliaBrain & Development, 1993
- Intracranial germ-cell tumors in childrenJournal of Neurosurgery, 1991
- Germ cell tumors of the thalamus and the basal gangliaChild's Nervous System, 1990
- Intracranial germ-cell tumors: natural history and pathogenesisJournal of Neurosurgery, 1985
- Unilateral germinomas involving the basal ganglia and thalamusJournal of Neurosurgery, 1981