Impact of long-term treatment of onchocerciasis with ivermectin in Ecuador: potential for elimination of infection
Open Access
- 23 May 2007
- journal article
- Published by Springer Science and Business Media LLC in BMC Medicine
- Vol. 5 (1), 9
- https://doi.org/10.1186/1741-7015-5-9
Abstract
Onchocerciasis is a leading cause of blindness worldwide, hence elimination of the infection is an important health priority. Community-based treatment programs with ivermectin form the basis of control programs for the disease in Latin America. The long-term administration of ivermectin could eliminate Onchocerca volvulus infection from endemic areas in Latin America. A strategy of annual to twice-annual treatments with ivermectin has been used for onchocerciasis in endemic communities in Ecuador for up to 14 years. The impact of ivermectin treatment on ocular morbidity, and O. volvulus infection and transmission was monitored in seven sentinel communities. Over the period 1990–2003, high rates of treatment coverage of the eligible population were maintained in endemic communities (mean 85.2% per treatment round). Ivermectin reduced the prevalence of anterior segment disease of the eye to 0% in sentinel communities and had a major impact on the prevalence and transmission of infection, with possible elimination of infection in some foci. The distribution of ivermectin in endemic communities in Ecuador might have eliminated ocular morbidity and significant progress has been made towards elimination of the infection. A strategy of more frequent treatments with ivermectin may be required in communities where the infection persists to achieve the objective of elimination of the infection from Ecuador. The elimination of the infection from an endemic country in Latin America would be a major public health achievement and could stimulate the implementation of elimination strategies in other endemic countries.Keywords
This publication has 32 references indexed in Scilit:
- Ivermectin selection on β-tubulin: Evidence in Onchocerca volvulus and Haemonchus contortusMolecular and Biochemical Parasitology, 2006
- Field Applicability of a Rapid‐Format Anti–Ov‐16 Antibody Test for the Assessment of Onchocerciasis Control Measures in Regions of EndemicityThe Journal of Infectious Diseases, 2006
- Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological studyThe Lancet, 2004
- Poliovirus?Specific Intestinal Antibody Responses Coincide with Decline of Poliovirus ExcretionThe Journal of Infectious Diseases, 2000
- Determining the Prevalence of Onchocerca volvulus Infection in Vector Populations by Polymerase Chain Reaction Screening of Pools of Black FliesThe Journal of Infectious Diseases, 1995
- Onchocerciasis in Ecuador: ocular findings in Onchocerca volvulus infected individuals.British Journal of Ophthalmology, 1995
- A clinical classification and grading system of the cutaneous changes in onchocerciasisBritish Journal of Dermatology, 1993
- Onchocerciasis in Ecuador: the situation in 1989Memórias do Instituto Oswaldo Cruz, 1992
- Impact of Mass Treatment of Onchocerciasis with Ivermectin on the Transmission of InfectionScience, 1990
- Identification of vector species (Diptera: Simuliidae) of human onchocerciasis in the Amazonia focus of Brazil and VenezuelaMemórias do Instituto Oswaldo Cruz, 1987