Skin protection creams in medical settings: successful or evil?
Open Access
- 25 July 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Occupational Medicine and Toxicology
- Vol. 3 (1), 15
- https://doi.org/10.1186/1745-6673-3-15
Abstract
Background Chronic exposure to mild irritants including cleansing and antiseptic products used for hand hygiene generates insults to the skin. To avoid unpleasant reactions, skin protection creams are commonly employed, but some fail to afford protection against a variety of xenobiotics. In this study, two skin protection creams were assayed comparatively looking for a protective effect if any against a liquid soap and an alcohol-based gel designed for hand hygiene in medical settings. Methods Corneosurfametry and corneoxenometry are two in vitro bioessays which were selected for their good reproducibility, sensitivity and ease of use. A Kruskal-Wallis ANOVA test followed by the Dunn test was realized to compare series of data obtained. Results Significant differences in efficacy were obtained between the two assayed skin protection creams. One of the two tested creams showed a real protective effect against mild irritants, but the other tested cream presented an irritant potential in its application with mild irritants. Conclusion The differences observed for the two tested skin protection creams were probably due to their galenic composition and their possible interactions with the offending products. As a result, the present in vitro bioassays showed contrasted effects of the creams corresponding to either a protective or an irritant effect on human stratum corneum.Keywords
This publication has 34 references indexed in Scilit:
- Regional variability in stratum corneum reactivity to antiseptic formulationsContact Dermatitis, 2007
- Using Skin Models to Assess the Effects of a Pre-Work CreamPublished by S. Karger AG ,2007
- An in vivo model to evaluate the efficacy of barrier creams on the level of skin penetration of chemicalsContact Dermatitis, 2006
- Using Skin Models to Assess the Effects of a Protection Cream on Skin Barrier FunctionSkin Pharmacology and Physiology, 2004
- Repair Kinetics of the Stratum corneum under Repeated InsultsExogenous Dermatology, 2004
- Barrier creams – skin protectants: can you protect skin?Journal of Cosmetic Dermatology, 2002
- Effect of Organic Solvents on Normal Human Stratum Corneum: Evaluation by the Corneoxenometry BioassayDermatology, 1997
- Sensitive skin and stratunm corneum reactivity to household cleaning productsContact Dermatitis, 1996
- Surfactant-induced dermatitis: Comparison of corneosurfametry with predictive testing on human and reconstructed skinJournal of the American Academy of Dermatology, 1995
- Corneosurfametry: A Predictive Assessment of the Interaction of Personal-Care Cleansing Products with Human Stratum corneumDermatology, 1994