Celiac disease associated with autoimmune myocarditis.
Open Access
- 4 June 2002
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 105 (22), 2611-2618
- https://doi.org/10.1161/01.cir.0000017880.86166.87
Abstract
Background — Both celiac disease (CD) and myocarditis can be associated with systemic autoimmune disorders; however, the coexistence of the 2 entities has never been investigated, although its identification may have a clinical impact. Methods and Results — We screened the serum of 187 consecutive patients with myocarditis (118 males and 69 females, mean age 41.7±14.3 years) for the presence of cardiac autoantibodies, anti–tissue transglutaminase (IgA-tTG), and anti-endomysial antibodies (AEAs). IgA-tTG–positive and AEA-positive patients underwent duodenal endoscopy and biopsy and HLA analysis. Thirteen of the 187 patients were positive for IgA-tTG, and 9 (4.4%) of them were positive for AEA. These 9 patients had iron-deficient anemia and exhibited duodenal endoscopic and histological evidence of CD. CD was observed in 1 (0.3%) of 306 normal controls ( P Conclusions — A common autoimmune process toward antigenic components of the myocardium and small bowel can be found in >4% of the patients with myocarditis. In these patients, immunosuppression and a gluten-free diet can be effective therapeutic options.Keywords
This publication has 19 references indexed in Scilit:
- Celiac SprueNew England Journal of Medicine, 2002
- Current concepts of celiac disease pathogenesisGastroenterology, 2000
- Giant Cell Myocarditis Responding to Immunosuppressive TherapyChest, 2000
- Prevalence of coeliac disease in idiopathic dilated cardiomyopathyThe Lancet, 1999
- Celiac Disease and Autoimmune Endocrinologic DisordersDigestive Diseases and Sciences, 1999
- Idiopathic Giant-Cell Myocarditis — Natural History and TreatmentNew England Journal of Medicine, 1997
- Coeliac diseaseThe Lancet, 1997
- Coeliac disease and autoimmune thyroid disease.Gut, 1994
- Celiac SprueNew England Journal of Medicine, 1991
- Active Myocarditis in the Spectrum of Acute Dilated CardiomyopathiesNew England Journal of Medicine, 1985