In vitro replication through nucleosomes without histone displacement
- 22 February 1990
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 343 (6260), 719-726
- https://doi.org/10.1038/343719a0
Abstract
A well-characterized set of proteins encoded by bacteriophage T4 replicates DNA in vitro and generates replication forks that can pass nucleo-somes. The histone octamers remain associated with newly replicated DNA even in the presence of excess DNA competitor, and intact nucleosomes re-form on the two daughter DNA helices. It is concluded that nucleosomes are designed to open up transiently to allow the passage of a replication fork without histone displacement.Keywords
This publication has 47 references indexed in Scilit:
- Prokaryotic DNA replication mechanismsPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1987
- Structure of replicating simian virus 40 minichromosomesJournal of Molecular Biology, 1986
- Psoralen-crosslinking of soluble and of H1-depleted soluble rat liver chromatinJournal of Molecular Biology, 1984
- Dispersive segregation of nucleosomes during replication of simian virus 40 chromosomesJournal of Molecular Biology, 1984
- Reversible changes in nucleosome structure and histone H3 accessibility in transcriptionally active and inactive states of rDNA chromatinCell, 1983
- Nucleosome segregation in chromatin replicated in the presence of cycloheximideJournal of Molecular Biology, 1982
- Unravelled nucleosomes, nucleosome beads and higher order structures of chromatin: Influence of non-histone components and histone H1Journal of Molecular Biology, 1981
- Structure of chromatin at deoxyribonucleic acid replication forks: Okazaki fragments released from replicating SV40 chromosomes by single-strand specific endonucleases are not in nucleosomesBiochemistry, 1979
- Salt-induced structural changes of nucleosome core particlesJournal of Molecular Biology, 1979
- Possible molecular mechanism for cell differentiation in multicellular organismsJournal of Theoretical Biology, 1971