Regulation of Porcine Endogenous Retrovirus Release by Porcine and Human Tetherins
- 1 March 2010
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 84 (5), 2618-2622
- https://doi.org/10.1128/jvi.01928-09
Abstract
The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering.This publication has 26 references indexed in Scilit:
- Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestrationProceedings of the National Academy of Sciences of the United States of America, 2009
- Antagonism to and Intracellular Sequestration of Human Tetherin by the Human Immunodeficiency Virus Type 2 Envelope GlycoproteinJournal of Virology, 2009
- Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin AntagonistsCell Host & Microbe, 2009
- Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2PLoS Pathogens, 2009
- Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAsXenotransplantation, 2009
- Inhibition of Lassa and Marburg Virus Production by TetherinJournal of Virology, 2009
- Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoproteinProceedings of the National Academy of Sciences of the United States of America, 2009
- Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by TetherinJournal of Virology, 2009
- Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain VariantsPLoS Pathogens, 2009
- The Restriction of Zoonotic PERV Transmission by Human APOBEC3GPLOS ONE, 2007