CLINICAL AND IMMUNOLOGICAL ASPECTS OF FOOD ALLERGY IN CHILDHOOD I. Estimation of IgG, IgA and IgE Antibodies to Food Antigens in Children with Food Allergy and Atopic Dermatitis

Abstract

Children (69) with case histories of food intolerance and 30 food tolerant children with atopic dermatitis were investigated regarding serum IgE [immunoglobulin E] levels and IgE, IgG and IgA-antibodies to some common foods. Children with food intolerance had significantly higher IgE levels and to a larger extent specific IgE antibodies to the tested allergens. IgE antibodies to cow''s milk were found in 71% of the children with histories of cow''s milk allergy but also occurred in similar titers in 27% of milk tolerant children with other food allergies. IgE antibodies to egg-white occurred in 88% of egg allergies, but low and moderate titers were also found in 17% of children without food intolerance. All children with high titers had symptoms of egg allergy. IgE antibodies to the fish allergen were only found in fish allergic children, while IgE antibodies to soybean and green peas were found less consistently. The level of serum IgA antibodies to milk was similar in both groups. The IgG antibody titers to all tested food antigens seemed to parallel the IgE antibody titer to the same food. It was not possible to correlate the IgG antibody titers to symptoms.