Lymphoblastic Lymphoma Expressing Natural Killer Cell Phenotype with Involvement of the Mediastinum and Nasal Cavity
- 1 February 1997
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 21 (2), 242-248
- https://doi.org/10.1097/00000478-199702000-00016
Abstract
Most CD56+ lymphomas display polymorphic and angiocentric/angiodestructive histologic features and are closely related to Epstein-Barr virus (EBV) infection. We report a 47-year-old Japanese man with CD56+ lymphoma that showed histologic features of lymphoblastic lymphoma with mediastinal and nasal involvement and an aggressive course. A sample specimen showed the histology of lymphoblastic lymphoma with a positive reaction for terminal deoxynucleotidyl transferase (TdT) but no angiocentric/angiodestructive features. Transmission electron microscopy revealed a few membrane-bound electrondense granules in their cytoplasm. Immunohistochemically, lymphoma cells exhibited CD56+ cytoplasmic CD3 (cCD3)+ TdT+. A Southern blot analysis showed no integration of EBV and human T-lymphotrophic virus 1 (HTLV-1) and no rearrangement of the T-cell receptors or immunoglobulin heavy chain genes. This unusual lymphoblastic lymphoma exhibiting cCD3+CD56+TdT+TCR− is assumed as an immature or progenitor natural killer cell lineage.Keywords
This publication has 35 references indexed in Scilit:
- Report of the Workshop on Nasal and Related Extranodal Angiocentric T/Natural Killer Cell LymphomasThe American Journal of Surgical Pathology, 1996
- Detection of Epstein-Barr Viral RNA in Malignant Lymphomas of the Upper Aerodigestive TractThe American Journal of Surgical Pathology, 1994
- Non-Hodgkin's Lymphomas of Nasal Cavity and Paranasal Sinuses An Immunohistochemical StudyAmerican Journal of Clinical Pathology, 1991
- PRESENCE OF EPSTEIN‐BARR VIRUS DNA IN NASAL LYMPHOMAS OF B AND ‘T’ CELL TYPEHematological Oncology, 1990
- Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granulomaThe Lancet, 1990
- Characteristics and uses of natural killer cellsImmunology Today, 1988
- Most Nasal/Nasopharyngeal Lymphomas are Peripheral T-Cell NeoplasmsThe American Journal of Surgical Pathology, 1987
- Pathologic and Clinical Spectrum of Post-Thymic T-Cell MalignanciesCancer Investigation, 1984
- Lymphoblastic Lymphoma with the Phenotype of Common Acute Lymphoblastic LeukemiaAmerican Journal of Clinical Pathology, 1983
- Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphomaBlood, 1981