Id2 and Id3 Inhibit Development of Cd34+ Stem Cells into Predendritic Cell (Pre-Dc)2 but Not into Pre-Dc1
- 18 December 2000
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 192 (12), 1775-1784
- https://doi.org/10.1084/jem.192.12.1775
Abstract
We found previously that Id3, which inhibits transcriptional activities of many basic helix-loop-helix transcription factors, blocked T and B cell development but stimulated natural killer (NK) cell development. Here we report that ectopic expression of Id3 and another Id protein, Id2, strongly inhibited the development of primitive CD34+CD38− progenitor cells into CD123high dendritic cell (DC)2 precursors. In contrast, development of CD34+CD38− cells into CD4+CD14+ DC1 precursors and mature DC1 was not affected by ectopic Id2 or Id3 expression. These observations support the notion of a common origin of DC2 precursors, T and B cells. As Id proteins did not block development of NK cells, a model presents itself in which these proteins drive common lymphoid precursors to develop into NK cells by inhibiting their options to develop into T cells, B cells, and pre-DC2.Keywords
This publication has 53 references indexed in Scilit:
- Generation of Interferon α–Producing Predendritic Cell (Pre-Dc)2 from Human Cd34+ Hematopoietic Stem CellsThe Journal of Experimental Medicine, 2000
- Commitment to the B Lymphoid Lineage Occurs before DH-JH RecombinationThe Journal of Experimental Medicine, 1999
- STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTORAnnual Review of Immunology, 1997
- The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-LigandThe Journal of Experimental Medicine, 1997
- Both E12 and E47 Allow Commitment to the B Cell LineageImmunity, 1997
- Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subsetImmunity, 1995
- Identification of a common T/natural killer cell progenitor in human fetal thymus.The Journal of Experimental Medicine, 1994
- Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor populationNature, 1993
- GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cellsNature, 1992
- Characterization of the Blood Mononuclear Leucocytes Producing Alpha Interferon after Stimulation with Herpes Simplex Virus in Vitro, by Means of Combined Immunohistochemical Staining and in Situ RNA‐RNA HybridizationScandinavian Journal of Immunology, 1989