Impedance Characterization and Modeling of Electrodes for Biomedical Applications
- 13 June 2005
- journal article
- research article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Engineering
- Vol. 52 (7), 1295-1302
- https://doi.org/10.1109/tbme.2005.847523
Abstract
A low electrode-electrolyte impedance interface is critical in the design of electrodes for biomedical applications. To design low-impedance interfaces a complete understanding of the physical processes contributing to the impedance is required. In this work a model describing these physical processes is validated and extended to quantify the effect of organic coatings and incubation time. Electrochemical impedance spectroscopy has been used to electrically characterize the interface for various electrode materials: platinum, platinum black, and titanium nitride; and varying electrode sizes: 1 cm/sup 2/, and 900 /spl mu/m/sup 2/. An equivalent circuit model comprising an interface capacitance, shunted by a charge transfer resistance, in series with the solution resistance has been fitted to the experimental results. Theoretical equations have been used to calculate the interface capacitance impedance and the solution resistance, yielding results that correspond well with the fitted parameter values, thereby confirming the validity of the equations. The effect of incubation time, and two organic cell-adhesion promoting coatings, poly-L-lysine and laminin, on the interface impedance has been quantified using the model. This demonstrates the benefits of using this model in developing a better understanding of the physical processes occurring at the interface in more complex, biomedically relevant situations.Keywords
This publication has 27 references indexed in Scilit:
- CMOS microelectrode array for the monitoring of electrogenic cellsBiosensors and Bioelectronics, 2004
- In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodesIEEE Transactions on Biomedical Engineering, 2002
- Impedance based DNA chip for direct Tm measurementTalanta, 2002
- Electric Cell–Substrate Impedance Sensing (ECIS) as a Noninvasive Means to Monitor the Kinetics of Cell Spreading to Artificial SurfacesExperimental Cell Research, 2000
- An array of Pt-tip microelectrodes for extracellular monitoring of activity of brain slicesBiosensors and Bioelectronics, 1999
- Capacitive monitoring of protein immobilization and antigen–antibody reactions on monomolecular alkylthiol films on gold electrodesBiosensors and Bioelectronics, 1997
- Electrocatalysts for O2 reductionElectrochimica Acta, 1984
- Oxygen cathodes for clinical measurementsPhysics in Medicine & Biology, 1973
- ELECTRODE POLARIZATION IMPEDANCE AND MEASUREMENTS IN BIOLOGICAL MATERIALS*Annals of the New York Academy of Sciences, 1968
- Fiftieth Anniversary: Mathematical Theory of the Faradaic AdmittanceJournal of the Electrochemical Society, 1952