Prevalence of sensitization to weed pollens of Humulus scandens, Artemisia vulgaris, and Ambrosia artemisiifolia in northern China
- 10 March 2013
- journal article
- Published by Zhejiang University Press in Journal of Zhejiang University-SCIENCE B
- Vol. 14 (3), 240-246
- https://doi.org/10.1631/jzus.b1200185
Abstract
Weed pollens are common sources of allergens worldwide. The prevalence of weed pollen sensitization is not yet fully known in China. The purpose of this study was to investigate the prevalence of sensitization to weed allergens from Artemisia, Ambrosia, and Humulus in northern China. A total of 1 144 subjects (aged from 5 to 68 years) visiting our clinic from June to October 2011 underwent intradermal testing using a panel of 25 allergen sources. Subjects with positive skin responses to any pollen were further tested for their serum concentrations of IgE antibodies against Artemisia vulgaris, Ambrosia artemisiifolia, and Humulus scandens, and against the purified allergens, Art v 1 and Amb a 1. Of 1 144 subjects, 170 had positive intradermal reactions to pollen and 144 donated serum for IgE testing. The prevalence of positive intradermal responses to pollens of Artemisia sieversiana, Artemisia annua, A. artemisiifolia, and H. scandens was 11.0%, 10.2%, 3.7%, and 6.6%, respectively. Among the intradermal positive subjects, the prevalence of specific IgE antigens to A. vulgaris was 58.3%, to A. artemisiifolia 14.7%, and to H. scandens 41.0%. The prevalence of specific IgE antigens to the allergen Art v 1 was 46.9%, and to Amb a 1 was 11.2%. The correlation between the presence of IgE antibodies specific to A. vulgaris and to the Art v 1 antigen was very high. Subjects with A. artemisiifolia specific IgE also had A. vulgaris specific IgE, but with relatively high levels of A. vulgaris IgE antibodies. There were no correlations between the presence of IgE antibodies to H. scandens and A. vulgaris or to H. scandens and A. artemisiifolia. The intradermal prevalence of weed pollen sensitization among allergic subjects in northern China is about 13.5%. Correlations of specific IgE antibodies suggest that pollen allergens from Artemisia and Humulus are independent sources for primary sensitization.Keywords
This publication has 21 references indexed in Scilit:
- Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients.2011
- Performance evaluation of a specific IgE assay developed for the ADVIA centaur® immunoassay systemClinical Biochemistry, 2004
- Monoclonal antibody‐based ELISA to quantify the major allergen of Artemisia vulgaris pollen, Art v 1Allergy, 2004
- Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin‐like and a hydroxyproline‐rich domainThe FASEB Journal, 2002
- Geographic and Time Trends of the Pollen Count Due to Beeches, Grass and Mugwort (Artemisia) in GermanyPneumologie, 2001
- Are There Any Links between Hop Japanese Pollen and Other Weed Pollens or Food Allergens on Skin Prick Tests?Allergy and Asthma Proceedings, 2001
- [Pollinosis: clinical aspects and epidemiology. Contribution of the Allergy Clinic 1948-1998].1998
- Mugwort and Sage (Artemisia) Pollen Cross-Reactivity: ELISA Inhibition and Immunoblot EvaluationAnnals of Allergy, Asthma & Immunology, 1997
- Atopic profile of inner-city asthma with a comparative analysis on the cockroach-sensitive and ragweed-sensitive subgroupsJournal of Allergy and Clinical Immunology, 1993
- City spore concentrations in the European Economic Community (EEC) IV. Summer weed pollen (Rumex, Plantago, Chenopodiaceae, Artemisia), 1976 and 1977Clinical & Experimental Allergy, 1980