Temperature-sensitive nanogels: poly(N-vinylcaprolactam) versus poly(N-isopropylacrylamide)
- 1 January 2012
- journal article
- Published by Royal Society of Chemistry (RSC) in Polymer Chemistry
- Vol. 3 (4), 852-856
- https://doi.org/10.1039/c2py00485b
Abstract
Poly(N-isopropylacrylamide) (PNIPAM) and poly(N-vinylcaprolactam) (PVCL) are temperature-responsive polymers which show a lower critical solution temperature (LCST) around 32 °C in aqueous solutions. Nanogels based on these temperature sensitive polymers swell at low temperatures and collapse at high ones, showing a volume phase transition temperature (VPTT) near physiological temperature. This unique behavior makes these nanogels attractive for biotechnological applications. PNIPAM is the building block of a huge amount of nanogels reported in the literature. However, PVCL is especially interesting due to the fact that it is very stable against hydrolysis and biocompatible. In this mini-review, various synthesis procedures together with the functionalization of different PNIPAM- and PVCL-based nanogels are revised and compared.Keywords
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