Associations of Birth Order With Early Growth and Adolescent Height, Body Composition, and Blood Pressure: Prospective Birth Cohort From Brazil
Open Access
- 22 September 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 174 (9), 1028-1035
- https://doi.org/10.1093/aje/kwr232
Abstract
Birth weight has been inversely associated with later blood pressure. Firstborns tend to have lower birth weight than their later-born peers, but the long-term consequences remain unclear. The study objective was to investigate differences between firstborn and later-born individuals in early growth patterns, body composition, and blood pressure in Brazilian adolescents. The authors studied 453 adolescents aged 13.3 years from the prospective 1993 Pelotas Birth Cohort. Anthropometry, blood pressure, physical activity by accelerometry, and body composition by deuterium were measured. Firstborns (n = 143) had significantly lower birth weight than later borns (n = 310). At 4 years, firstborns had significantly greater weight and height, indicating a substantial overshoot in catch-up growth. In adolescence, firstborns had significantly greater height and blood pressure and a lower activity level. The difference in systolic blood pressure could be attributed to variability in early growth and that in diastolic blood pressure to reduced physical activity. The magnitude of increased blood pressure is clinically significant; hence, birth order is an important developmental predictor of cardiovascular risk in this population. Firstborns may be more sensitive to environmental factors that promote catch-up growth, and this information could potentially be used in nutritional management to prevent catch-up “overshoot.”Keywords
This publication has 51 references indexed in Scilit:
- First-Borns Carry a Higher Metabolic Risk in Early Adulthood: Evidence from a Prospective Cohort StudyPLOS ONE, 2010
- Pediatric reference data for lean tissue properties: density and hydration from age 5 to 20 yThe American Journal of Clinical Nutrition, 2010
- Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheepJournal of Endocrinology, 2010
- Does lower birth order amplify the association between high socioeconomic status and central adiposity in young adult Filipino males?International Journal of Obesity, 2010
- Maternal and child undernutrition: consequences for adult health and human capitalThe Lancet, 2008
- Rapid infancy weight gain and subsequent obesity: Systematic reviews and hopeful suggestionsActa Paediatrica, 2006
- HEIGHTS AND WEIGHTS OF DA-AN BOYS: DID SISTERS REALLY MAKE A DIFFERENCE?Journal of Biosocial Science, 2004
- Birth weights in three Norwegian cities, 1860–1984. Secular trends and influencing factorsAnnals of Human Biology, 1988
- Effects of Parity on Birth Weight and Other Variables in a Tanganyika Bantu SampleJournal of Epidemiology and Community Health, 1963