Population approaches in paediatrics
- 1 December 2008
- journal article
- research article
- Published by Wiley in Fundamental & Clinical Pharmacology
- Vol. 22 (6), 575-578
- https://doi.org/10.1111/j.1472-8206.2008.00647.x
Abstract
Population pharmacokinetic (PK) approach is now often used to evaluate PK characteristics of a new compound during its clinical development. Recently, new legislation governing the development and authorization of medicines for use in children aged 0-17 years was introduced in the European Union. Among the strategies proposed in relation to clinical aspects, use of population PKs is stated. In this manuscript, comparison between standard PK and population PK methods will be briefly addressed to understand why the second is particularly adapted to perform PK studies in paediatrics. Then, specific patients' characteristics (covariates) in paediatrics will be presented. Examples of PK and PK-pharmacodynamic (PK-PD) studies will be finally given. The number of population PK studies published still exceeds largely those of PK-PD.Keywords
This publication has 16 references indexed in Scilit:
- Facilitation of Drug Evaluation in Children by Population Methods and Modelling†Clinical Pharmacokinetics, 2008
- Population Pharmacokinetics of Cefepime in the NeonateAntimicrobial Agents and Chemotherapy, 2005
- Population pharmacokinetic studies in pediatrics: Issues in design and analysisThe AAPS Journal, 2005
- Ontogeny of drug metabolizing enzymes in the neonateSeminars in Fetal and Neonatal Medicine, 2005
- The utility of mixed‐effects covariate analysis in rapid selection of doses in pediatric subjects: A case study with fexofenadine hydrochlorideBiopharmaceutics & Drug Disposition, 2004
- Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and ChildrenNew England Journal of Medicine, 2003
- The Effect of Age on the Apparent Clearance of Felbamate: A Retrospective Analysis Using Nonlinear Mixed-Effects ModelingTherapeutic Drug Monitoring, 1996
- Clinical Pharmacokinetics in Infants and Children A ReappraisalClinical Pharmacokinetics, 1989
- WATER DISTRIBUTION IN THE FOETUS AND NEWBORN INFANTActa Paediatrica, 1983
- Prenatal and neonatal drug metabolism in manEuropean Journal of Clinical Pharmacology, 1980