Oral health in geroscience: animal models and the aging oral cavity
- 27 December 2017
- journal article
- review article
- Published by Springer Science and Business Media LLC in GeroScience
- Vol. 40 (1), 1-10
- https://doi.org/10.1007/s11357-017-0004-9
Abstract
Age is the single greatest risk factor for many diseases, including oral diseases. Despite this, a majority of preclinical oral health research has not adequately considered the importance of aging in research aimed at the mechanistic understanding of oral disease. Here, we have attempted to provide insights from animal studies in the geroscience field and apply them in the context of oral health research. In particular, we discuss the relationship between the biology of aging and mechanisms of oral disease. We also present a framework for defining and utilizing age-appropriate rodents and present experimental design considerations, such as the number of age-points used and the importance of genetic background. While focused primarily on rodent models, alternative animal models that may be particularly useful for studies of oral health during aging, such as companion dogs and marmoset monkeys, are also discussed. We hope that such information will aid in the design of future preclinical studies of geriatric dental health, thus allowing more reliability for translation of such studies to age-associated oral disease in people.This publication has 79 references indexed in Scilit:
- The Hallmarks of AgingCell, 2013
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA studyNature, 2012
- Human gut microbiome viewed across age and geographyNature, 2012
- Epigenetic regulation of human β-defensin 2 and CC chemokine ligand 20 expression in gingival epithelial cells in response to oral bacteriaMucosal Immunology, 2011
- Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levelsAging Cell, 2009
- Mouse model of experimental periodontitis induced by Porphyromonas gingivalis/Fusobacterium nucleatum infection: bone loss and host responseJournal of Clinical Periodontology, 2009
- Design of aging intervention studies: the NIA interventions testing programAGE, 2008
- The use of rodent models to investigate host–bacteria interactions related to periodontal diseasesJournal of Clinical Periodontology, 2008
- Immunosenescence of ageingThe Journal of Pathology, 2007
- Periodontal disease and systemic conditions: a bidirectional relationshipOdontology, 2006