Tick-Borne Zoonoses in the United States: Persistent and Emerging Threats to Human Health
Top Cited Papers
Open Access
- 23 March 2017
- journal article
- review article
- Published by Oxford University Press (OUP) in ILAR Journal
- Vol. 58 (3), 319-335
- https://doi.org/10.1093/ilar/ilx005
Abstract
In the United States, ticks transmit the greatest diversity of arthropod-borne pathogens and are responsible for the most cases of all vector-borne diseases. In recent decades, the number of reported cases of notifiable tick-borne diseases has steadily increased, geographic distributions of many ticks and tick-borne diseases have expanded, and new tick-borne disease agents have been recognized. In this review, we (1) describe the known disease agents associated with the most commonly human-biting ixodid ticks, (2) review the natural histories of these ticks and their associated pathogens, (3) highlight spatial and temporal changes in vector tick distributions and tick-borne disease occurrence in recent decades, and (4) identify knowledge gaps and barriers to more effective prevention of tick-borne diseases. We describe 12 major tick-borne diseases caused by 15 distinct disease agents that are transmitted by the 8 most commonly human-biting ixodid ticks in the United States. Notably, 40% of these pathogens were described within the last two decades. Our assessment highlights the importance of animal studies to elucidate how tick-borne pathogens are maintained in nature, as well as advances in molecular detection of pathogens which has led to the discovery of several new tick-borne disease agents.Keywords
This publication has 188 references indexed in Scilit:
- Beyond Lyme: Aetiology of Tick‐borne Human Diseases with Emphasis on the South‐Eastern United StatesZoonoses and Public Health, 2012
- Distribution of Rickettsia rickettsii in ovary cells of Rhipicephalus sanguineus (Latreille1806) (Acari: Ixodidae)Parasites & Vectors, 2011
- Emergence of a New Pathogenic Ehrlichia Species, Wisconsin and Minnesota, 2009The New England Journal of Medicine, 2011
- Biology and ecology of the brown dog tick, Rhipicephalus sanguineusParasites & Vectors, 2010
- Reservoir Competence of the Redwood Chipmunk (Tamias Ochrogenys) forAnaplasma PhagocytophilumVector-Borne and Zoonotic Diseases, 2009
- Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir SpeciesThe American Journal of Tropical Medicine and Hygiene, 2009
- Francisella tularensis: an arthropod-borne pathogenVeterinary Research, 2008
- Anaplasma phagocytophilumInfection in Small Mammal Hosts ofIxodesTicks, Western United StatesEmerging Infectious Diseases, 2008
- Gulf Coast Ticks (Amblyomma maculatum) andRickettsia parkeri,United StatesEmerging Infectious Diseases, 2007
- Isolation and Identification ofRickettsia massiliaefromRhipicephalus sanguineusTicks Collected in ArizonaApplied and Environmental Microbiology, 2006