Healthy sibling donor anxiety and pain during bone marrow or peripheral blood stem cell harvesting for allogeneic transplantation: results of a randomised study
- 1 January 2002
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 29 (2), 145-149
- https://doi.org/10.1038/sj.bmt.1703338
Abstract
This study reports the first comparison of healthy donor subjective well-being during two alternative procedures of hematopoietic stem cells harvesting for allogeneic transplantation. Among the 105 donors included between September 1996 and October 1998 in the SFGM French randomised trial aiming to compare allogeneic bone marrow (BM) transplantation and blood cell (BC) transplantation, 64 donors (33 in BC and 31 in BM groups) were relevant for the analysis. They had received a set of self-administered questionnaires to complete during the collection process, aiming to measure anxiety (assessed using the Spielberger's State-Trait Anxiety Inventory) and pain induced by the procedure (evaluated using a visual analogical scale). Results showed that no harvest procedure is free from pain even if none was more painful than the other. Levels of anxiety before the collection procedure were high in both groups and significantly so for BC donors. Although BC collection induces at least similar levels of pain and anxiety as does BM collection, they were of a different kind, and the short-term impact of G-CSF stimulation on the well-being of BC donors has to be taken into account in improving quality of care in the allogeneic setting. Bone Marrow Transplantation (2002) 29, 145–149. doi:10.1038/sj.bmt.1703338Keywords
This publication has 13 references indexed in Scilit:
- Psychosocial aspects of haematopoietic stem cell donation for allogeneic transplantation: how family donors cope with this experiencePsycho‐Oncology, 1999
- Allogeneic bone marrow transplantation vs filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia: first results of a randomised multicentre trial of the European Group for Blood and Marrow TransplantationBone Marrow Transplantation, 1998
- Discordance between physicians' estimations and breast cancer patients' self-assessment of side-effects of chemotherapy: an issue for quality of careBritish Journal of Cancer, 1997
- Peripheral Blood Stem Cell and Bone Marrow Transplantation for Solid Tumors and Lymphomas: Hematologic Recovery and Costs: A Randomized, Controlled TrialAnnals of Internal Medicine, 1997
- Blood and marrow transplantation activity in Europe 1995Bone Marrow Transplantation, 1997
- Blood counts in healthy donors 1 year after the collection of granulocyte-colony-stimulating factor-mobilized progenitor cells and the results of a second mobilization and collectionTransfusion, 1997
- Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patientsThe Lancet, 1996
- Adaptation canadienne-française de la forme révisée du State–Trait Anxiety Inventory de Spielberger.Canadian Journal of Behavioural Science / Revue canadienne des sciences du comportement, 1993
- PSYCHOLOGICAL ADJUSTMENT OF ADULT BONE MARROW TRANSPLANT DONORS WHOSE RECIPIENT SURVIVESTransplantation, 1986
- MEASUREMENT OF PAINThe Lancet, 1974