Formulation of wax oxybenzone microparticles using a factorial approach
- 3 August 2010
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Microencapsulation
- Vol. 27 (7), 628-639
- https://doi.org/10.3109/02652048.2010.506580
Abstract
Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 2⁴ experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5–88.1 μm size range, 17.8–38.9 drug content in mg/100 mg MPs and 33.1–87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance.Keywords
This publication has 42 references indexed in Scilit:
- Chitosan microparticles incorporating a hydrophilic sunscreen agentCarbohydrate Polymers, 2010
- Solid lipid nanoparticles bearing oxybenzone:In-vitroandin-vivoevaluationJournal of Microencapsulation, 2010
- Evaluation of spray congealing as technique for the preparation of highly loaded solid lipid microparticles containing the sunscreen agent, avobenzoneJournal of Pharmaceutical Sciences, 2009
- The latest on skin photoprotectionClinics in Dermatology, 2008
- Microsphere Based Improved Sunscreen Formulation of Ethylhexyl MethoxycinnamateCurrent Drug Delivery, 2007
- Formulation optimization for the nanoparticles-in-microsphere hybrid oral delivery system using factorial designJournal of Controlled Release, 2006
- Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiationBritish Journal of Dermatology, 2005
- Skin electroporation for transdermal and topical deliveryAdvanced Drug Delivery Reviews, 2004
- Influence of Cyclodextrin Complexation on the In Vivo Photoprotective Effects of OxybenzoneDrug Development and Industrial Pharmacy, 2004
- Influence of Hydroxypropyl- ?-Cyclodextrin on the Transdermal Permeation and Skin Accumulation of OxybenzoneDrug Development and Industrial Pharmacy, 2002