Role of PM2.5 in the development and progression of COPD and its mechanisms
Open Access
- 13 June 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 20 (1), 1-13
- https://doi.org/10.1186/s12931-019-1081-3
Abstract
A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted this study to investigate the role of PM2.5 in the development of COPD and associated mechanisms. We firstly conducted a cross-sectional study in Chinese han population to observe PM2.5 effects on COPD morbidity. Then, in vitro, we incubated human bronchial epithelial cells to different concentrations of PM2.5 for 24 h. The expression levels of IL-6 and IL-8 were detected by ELISA and the levels of MMPs, TGF-β1, fibronectin and collagen was determined by immunoblotting. In vivo, we subjected C57BL/6 mice to chronic prolonged exposure to PM2.5 for 48 weeks to study the influence of PM2.5 exposure on lung function, pulmonary structure and inflammation. We found that the effect of PM2.5 on COPD morbidity was associated with its levels and that PM2.5 and cigarette smoke could have a synergistic impact on COPD development and progression. Both vitro and vivo studies demonstrated that PM2.5 exposure could induce pulmonary inflammation, decrease lung function, and cause emphysematous changes. Furthermore, PM2.5 could markedly aggravated cigarette smoke-induced changes. In short, we found that prolonged chronic exposure to PM2.5 resulted in decreased lung function, emphysematous lesions and airway inflammation. Most importantly, long-term PM2.5 exposure exacerbateed cigarette smoke-induced changes in COPD.Keywords
Funding Information
- National Natural Science Foundation of China (81570033, 81570047, 81470227, 81370145, 81370156, 81670035)
- National Key Basic Research and Development Program (20l5CB553403)
- Chinese medical association research project (2013BAI09B00)
- National Key Technologies R&D Program (2016YFC1303900 and 2016YFC1304700)
- National Key Research and Development Program in China (2016YFC0903600)
- Changjiang Scholars and Innovative Research Team in University (No. IRT_14R20)
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