Markerless lung tumor tracking and trajectory reconstruction using rotational cone-beam projections: a feasibility study
- 14 April 2010
- journal article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 55 (9), 2505-2522
- https://doi.org/10.1088/0031-9155/55/9/006
Abstract
Algorithms for direct tumor tracking in rotational cone-beam projections and for reconstruction of phase-binned 3D tumor trajectories were developed. The feasibility of the algorithm was demonstrated on a digital phantom, a physical phantom and two patients. Tracking results were obtained by comparing reference templates generated from 4DCT to rotational cone-beam projections. The 95th percentile absolute errors (e(95)) in phantom tracking results did not exceed 1.7 mm in either imager dimension, while e(95) in the patients was 3.3 mm or less. Accurate phase-binned trajectories were reconstructed in each case, with 3D maximum errors of no more than 1.0 mm in the phantoms and 2.0 mm in the patients. This work shows the feasibility of a direct tumor tracking technique for rotational images, and demonstrates that an accurate 3D tumor trajectory can be reconstructed from relatively less accurate tracking results. The ability to reconstruct the tumor's average trajectory from a 3D cone-beam CT scan on the day of treatment could allow for better patient setup and quality assurance, while direct tumor tracking in rotational projections could be clinically useful for rotational therapy such as volumetric modulated arc therapy (VMAT).Keywords
This publication has 37 references indexed in Scilit:
- Cone‐beam CT image reconstruction with extended rangeMedical Physics, 2009
- The diaphragm as an anatomic surrogate for lung tumor motionPhysics in Medicine & Biology, 2009
- A framelet-based image inpainting algorithmApplied and Computational Harmonic Analysis, 2008
- Multiple template-based fluoroscopic tracking of lung tumor mass without implanted fiducial markersPhysics in Medicine & Biology, 2007
- Total Variation Wavelet InpaintingJournal of Mathematical Imaging and Vision, 2006
- Residual motion of lung tumours in gated radiotherapy with external respiratory surrogatesPhysics in Medicine & Biology, 2005
- Accuracy of a wireless localization system for radiotherapyInternational Journal of Radiation Oncology*Biology*Physics, 2005
- CT-guided Transthoracic Needle Aspiration Biopsy of Pulmonary Nodules: Needle Size and Pneumothorax RateRadiology, 2003
- The effect of breathing and set-up errors on the cumulative dose to a lung tumorRadiotherapy and Oncology, 2001
- Practical cone-beam algorithmJournal of the Optical Society of America A, 1984