Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity
- 1 December 2003
- journal article
- case report
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 76 (912), 916-919
- https://doi.org/10.1259/bjr/77297900
Abstract
FK506 is a newly developed potent immunosuppressant for preventing rejection after organ transplantation. However, FK506 can induce central nervous system toxicity. Until now the pathogenic mechanism of FK506 neurotoxicity was unclear. We report the findings of diffusion-weighted MRI and apparent diffusion coefficient (ADC) mapping of a FK506 neurotoxicity patient who showed increased signal intensities in both parieto-occipital lobes on T2 weighted images, diffusion-weighted images and ADC maps. These findings suggest that a vasogenic oedema rather than a cytotoxic oedema may play a pivotal role in FK506 neurotoxicity pathogenesis.Keywords
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