Severe Dysosmia Is Specifically Associated with Alzheimer-Like Memory Deficits in Nondemented Elderly Retirees
- 15 March 2002
- journal article
- Published by S. Karger AG in Neuroepidemiology
- Vol. 21 (2), 68-73
- https://doi.org/10.1159/000048619
Abstract
To determine whether or not (1) impaired olfactory function is associated with impaired memory on neuropsychological testing in healthy retirees, and if so then (2) whether memory impairment is most consistent with a mesiotemporal rather than frontal system disorder. 173 independent residents of a continuing care retirement community were studied. Subjects completed the University of Pennsylvania Smell Identification Test (UPSIT) and a battery of both general and specific cognitive measures that included the Mini-Mental State Examination (MMSE) and the Executive Interview (EXIT25). Subjects were examined twice over 3 years. UPSIT performance was normal in 21% and in the 'anosmic' range in 25% of subjects. Anosmic UPSIT performance was associated with significantly worse performance on all cognitive tests. However, only short-term verbal memory was independently associated with UPSIT-defined anosmia. This association remained significant after adjusting for the other cognitive and sociodemographic variables. The memory deficits of anosmic subjects were qualitatively consistent with a cortical type (type 1) dementing illness such as Alzheimer's disease (AD). Over time, UPSIT-defined 'anosmic' cases suffered significantly greater declines on both the MMSE and the EXIT25, independently of baseline age, gender and MMSE score. Impaired odor identification in individuals without overt dementia is associated with an AD-like memory impairment and an increased rate of cognitive decline. The comorbid association of these deficits is consistent with the known hierarchical spread of preclinical AD pathology and may be a specific indicator of future clinical AD dementia.Keywords
This publication has 9 references indexed in Scilit:
- Pathological Determinants of the Transition to Clinical Dementia in Alzheimer's DiseaseExperimental Aging Research, 2002
- Frontal MRI Findings Associated With Impairment on the Executive Interview (EXIT25)Experimental Aging Research, 2001
- Olfactory Deficits in Patients With Mild Cognitive Impairment Predict Alzheimer’s Disease at Follow-UpAmerican Journal of Psychiatry, 2000
- Memory failure has different mechanisms in subcortical stroke and Alzheimer's diseaseAnnals of Neurology, 2000
- Olfaction in Neurodegenerative DiseaseArchives of Neurology, 1998
- Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's diseaseNeuroscience Letters, 1996
- Impaired sensory and cognitive olfactory function in questionable Alzheimer's disease.Neuropsychology, 1996
- Posttraumatic anosmia and orbital frontal damage: Neuropsychological and neuropsychiatric correlates.Neuropsychology, 1991
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975