Risk of herpes zoster among patients with chronic obstructive pulmonary disease: a population-based study
- 22 February 2011
- journal article
- research article
- Published by CMA Impact Inc. in CMAJ : Canadian Medical Association Journal
- Vol. 183 (5), E275-E280
- https://doi.org/10.1503/cmaj.101137
Abstract
Background Systemic inflammation and dysregulated immune function in chronic obstructive pulmonary disease (COPD) is hypothesized to predispose patients to development of herpes zoster. However, the risk of herpes zoster among patients with COPD is undocumented. We therefore aimed to investigate the risk of herpes zoster among patients with COPD. Methods We conducted a cohort study using data from the Taiwan Longitudinal Health Insurance Database. We performed Cox regressions to compare the hazard ratio (HR) of herpes zoster in the COPD cohort and in an age- and sex-matched comparison cohort. We divided the patients with COPD into three groups according to use of steroid medications and performed a further analysis to examine the risk of herpes zoster. Results The study included 8486 patients with COPD and 33 944 matched control patients. After adjustment for potential confounding factors, patients with COPD were more likely to have incidents of herpes zoster (adjusted HR 1.68, 95% confidence interval [CI] 1.45–1.95). When compared with the comparison cohort, the adjusted HR of herpes zoster was 1.67 (95% CI 1.43–1.96) for patients with COPD not taking steroid medications. The adjusted HR of herpes zoster was slightly greater for patients with COPD using inhaled corticosteroids only (adjusted HR 2.09, 95% CI 1.38–3.16) and was greatest for patients with COPD using oral steroids (adjusted HR 3.00, 95% CI 2.40–3.75). Interpretation Patients with COPD were at increased risk of herpes zoster relative to the general population. The relative risk of herpes zoster was greatest for patients with COPD using oral steroids.This publication has 29 references indexed in Scilit:
- The impact of herpes zoster and post-herpetic neuralgia on quality-of-lifeBMC Medicine, 2010
- Use of High-Dose Inhaled Corticosteroids is Associated With Pulmonary Tuberculosis in Patients With Chronic Obstructive Pulmonary DiseaseMedicine, 2010
- The Charlson comorbidity index (CCI) for adjustment of hip fracture mortality in the elderly: analysis of the importance of recording secondary diagnosesCadernos de Saude Publica, 2008
- The risk of herpes zoster in patients with rheumatoid arthritis in the United States and the United KingdomArthritis Care & Research, 2007
- Urbanicity and Methods of Suicide: A Nationwide Population-based StudyJournal of Urban Health, 2007
- Incidence and Risk Factors for Herpes Zoster Among Patients With Inflammatory Bowel DiseaseClinical Gastroenterology and Hepatology, 2006
- A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older AdultsThe New England Journal of Medicine, 2005
- Preventing Varicella-Zoster DiseaseClinical Microbiology Reviews, 2005
- Effect of prolonged use of inhaled steroids on the cellular immunity of children with asthmaJournal of Allergy and Clinical Immunology, 1995
- Severe chickenpox after intranasal use of corticosteroidsThe Journal of Pediatrics, 1993