Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Small, Dense LDL Particles in Human Plasma
Open Access
- 1 December 2005
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 51 (12), 2264-2273
- https://doi.org/10.1373/clinchem.2005.058404
Abstract
Background: Recent clinical studies showed that lipoprotein-associated phospholipase A2 (Lp-PLA2) is a predictor for incident atherosclerotic disease. We have previously shown that among the LDL subfractions, Lp-PLA2 activity is preferentially associated with the atherogenic small, dense (sdLDL) particles in vitro. We investigated whether Lp-PLA2 could be a marker of sdLDL in human plasma.Keywords
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