5?-Nucleotidase activity in human astrocytomas
- 1 January 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Acta Neuropathologica
- Vol. 59 (2), 145-149
- https://doi.org/10.1007/bf00691601
Abstract
Human astrocytomas contain 5′-nucleotidase as shown using histochemical, cytochemical and biochemical techniques. 5′-Nucleotidase activity was revealed by electron microscopy to be associated with the outer surface of the plasma membrane of astrocytoma cells. The results confirm and extend previous reports of the localisation of 5′-nucleotidase in normal astrocytes in situ. Biochemical assay of 5′-nucleotidase activity in 35 tumours showed it to be clearly higher in malignant (anaplastic astrocytomas and glioblastomas) than in benign astrocytomas.This publication has 17 references indexed in Scilit:
- Cytochemical heterogeneity of the glial plasma membrane: 5′-nucleotidase in retinal Müller cellsJournal of Neurocytology, 1982
- The role of adenosine and its nucleotides in central synaptic transmissionProgress in Neurobiology, 1981
- Induction of fiber outgrowth in PC12 pheochromocytoma cells by a neuronotrophic factor occurring in human tumorsActa Neuropathologica, 1981
- Stimulation of the plasma membrane enzyme, 5′-nucleotidase, by ethanol exposure to neural cells in cultureProgress in Neuro-Psychopharmacology, 1980
- Modulation of neurotransmission by purine nucleotides and nucleosidesBiochemical Pharmacology, 1980
- Cytochemical localization of 5′-nucleotidase in glial plasma membranesBrain Research, 1978
- 5?-Nucleotidase of microglial cells in the facial nucleus during axonal reactionJournal of Neurocytology, 1978
- A simple, specific, radioisotopic assay for 5′-nucleotidaseAnalytical Biochemistry, 1975
- Structures and organization of cell surface glycolipids dependency on cell growth and malignant transformationBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1975
- Release of Adenosine from Ischemic BrainCirculation Research, 1974