Vitamin D and Risk of Cognitive Decline in Elderly Persons
- 12 July 2010
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Internal Medicine
- Vol. 170 (13), 1135-1141
- https://doi.org/10.1001/archinternmed.2010.173
Abstract
It is estimated that between 40% and 100% of older, community-living adults in the United States and Europe are vitamin D deficient.1 Vitamin D deficiency is associated with fractures, various chronic conditions, and mortality.2-5 Cognitive decline and dementia are also common in older adults, although their causes remain unclear.6-8 Vitamin D may help to prevent neurodegeneration because it plays an important role in the expression of neurotrophic factors, neurogenesis, calcium homeostasis, detoxification, and β-amyloid clearance.9-11Keywords
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