High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus
- 21 April 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 119 (15), 2103-2111
- https://doi.org/10.1161/circulationaha.108.843219
Abstract
Background— Low plasma high-density lipoprotein (HDL) is associated with elevated cardiovascular risk and aspects of the metabolic syndrome. We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle. Methods and Results— Thirteen patients with type 2 diabetes mellitus received both intravenous reconstituted HDL (rHDL: 80 mg/kg over 4 hours) and placebo on separate days in a double-blind, placebo-controlled crossover study. A greater fall in plasma glucose from baseline occurred during rHDL than during placebo (at 4 hours rHDL=−2.6±0.4; placebo=−2.1±0.3mmol/L; P=0.018). rHDL increased plasma insulin (at 4 hours rHDL=3.4±10.0; placebo= −19.2±7.4 pmol/L; P=0.034) and also the homeostasis model assessment β-cell function index (at 4 hours rHDL=18.9±5.9; placebo=8.6±4.4%; P=0.025). Acetyl-CoA carboxylase β phosphorylation in skeletal muscle biopsies was increased by 1.7±0....Keywords
This publication has 36 references indexed in Scilit:
- Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitusDiabetologia, 2008
- Effects of Torcetrapib in Patients at High Risk for Coronary EventsNew England Journal of Medicine, 2007
- The Role of Different Regions of ATP-Binding Cassette Transporter A1 in Cholesterol EffluxBiochemistry, 2007
- ATP-Binding Cassette Transporter A1 Modulates Apolipoprotein A-I Transcytosis Through Aortic Endothelial CellsCirculation Research, 2006
- Ca2+–calmodulin‐dependent protein kinase expression and signalling in skeletal muscle during exerciseThe Journal of Physiology, 2006
- AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolismCell Metabolism, 2005
- Peroxisome Proliferator–Activated Receptor Ligand Bezafibrate for Prevention of Type 2 Diabetes Mellitus in Patients With Coronary Artery DiseaseCirculation, 2004
- Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseNature, 2002
- Exercise Induces Isoform-Specific Increase in 5′AMP-Activated Protein Kinase Activity in Human Skeletal MuscleBiochemical and Biophysical Research Communications, 2000
- High-Density Lipoprotein — The Clinical Implications of Recent StudiesThe New England Journal of Medicine, 1989