Microevolution of Mycobacterium tuberculosis in a Tuberculosis Patient
- 1 October 2010
- journal article
- case report
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 48 (10), 3813-3816
- https://doi.org/10.1128/jcm.00556-10
Abstract
F ive Mycobacterium tuberculosis isolates were obtained from three body sites from a Dutch patient. The isolates displayed a single genotype by 24-locus MIRU-VNTR typing (except for a single locus not amplified from one isolate) but were differentiated by small variations in IS 6110 fingerprints, spoligotypes, 6 hypervariable MIRU-VNTR loci, and/or DiversiLab profiles, revealing patterns of microevolution in a clonal infection.Keywords
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