Association Between Sodium Intake and Change in Uric Acid, Urine Albumin Excretion, and the Risk of Developing Hypertension
- 26 June 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 125 (25), 3108-3116
- https://doi.org/10.1161/circulationaha.112.096115
Abstract
Background— A high-sodium diet has little short-term effect on blood pressure in nonhypertensive individuals but, for unclear reasons, is associated with hypertension if consumed long term. We hypothesized that a chronically high sodium intake would be associated with increases in biomarkers of endothelial dysfunction, specifically serum uric acid (SUA) and urine albumin excretion (UAE), and that high sodium intake would be associated with incident hypertension among those with higher SUA and UAE. Methods and Results— We prospectively analyzed the associations between sodium intake and the change in SUA (n=4062) and UAE (n=4146) among participants of the Prevention of Renal and Vascular End Stage Disease (PREVEND) study who were not taking antihypertensive medications. We also examined the association of sodium intake with the incidence of hypertension (n=5556) among nonhypertensive participants. After adjustment for confounders, each 1-g-higher sodium intake was associated with a 1.2-μmol/L increase in SUA (P=0.01) and a 4.6-mg/d increase in UAE (P<0.001). The relation between sodium intake and incident hypertension varied according to SUA and UAE. For each 1-g-higher sodium intake, the adjusted hazard ratio for developing hypertension was 0.98 (95% confidence interval, 0.89–1.08) among those in the lowest tertile of SUA and 1.09 (1.02–1.16) among those in the highest tertile. Corresponding hazard ratios were 0.99 (confidence interval, 0.93–1.06) among participants whose UAE was 15 mg/d. Conclusions— Over time, higher sodium intake is associated with increases in SUA and UAE. Among individuals with higher SUA and urine UAE, a higher sodium intake is an independent risk factor for developing hypertension.Keywords
This publication has 62 references indexed in Scilit:
- Association between endothelial dysfunction and hyperuricaemiaRheumatology, 2010
- Projected Effect of Dietary Salt Reductions on Future Cardiovascular DiseaseThe New England Journal of Medicine, 2010
- Uric Acid and Insulin Sensitivity and Risk of Incident HypertensionJAMA Internal Medicine, 2009
- Higher Levels of Albuminuria within the Normal Range Predict Incident HypertensionJournal of the American Society of Nephrology, 2008
- Endothelial function and urine albumin levels among asymptomatic Mexican-Americans and non-Hispanic whitesCardiovascular Ultrasound, 2008
- Adverse Cardiovascular Effects of Acute Salt Loading in Young Normotensive IndividualsHypertension, 2008
- Low-Grade Albuminuria and the Risks of Hypertension and Blood Pressure ProgressionCirculation, 2005
- Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureHypertension, 2003
- Microalbuminuria in salt-sensitive patients. A marker for renal and cardiovascular risk factors.Hypertension, 1994
- Cardiovascular and humoral responses to extremes of sodium intake in normal black and white men.Circulation, 1979